PSYCHOPHARMACOLOGICAL TARGETS IN PERSONALIZED PSYCHIATRY

The advances made on genetic influence response and side effects of psychiatric pharmacotherapy improved the concept personalized psychiatry. current evidence suggests that testing can be useful in patients who did not respond or tolerate at least one previous pharmacotherapy. Approximately 90% all drugs are metabolized by only few different cytochrome enzymes. Pharmacogenetic research has provided important CYP functional polymorphisms treatment, with numerous studies associating their presence variability observed to treatment. study candidate genes involved pharmacokinetics antidepressants sufficiently strong scientific for clinical applications. These encode P450 enzymes responsible metabolism antidepressants. is thus becoming a increasingly tool antidepressant efficacy action been associated several polymorphisms, located gene encoding proteins considered various mechanisms treatments.